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Keywords
Abstract
Aim: To evaluate the diagnostic accuracy of the ratio of circumpapillary retinal nerve fiber layer thickness (cpRNFLT) to macular outer retinal thickness (R/O ratio) and the ratio of ganglion cell complex (GCC) thickness to outer retinal thickness (G/O ratio) measured with the RTVue-100 Fourier-domain optical coherence tomograph for detecting early glaucoma in Japanese eyes.
Methods: Forty-seven healthy control, 31 preperimetric and 70 early perimetric glaucoma eyes. We used cpRNFLT and macular retinal thickness measurements to calculate new ratio parameters, and to compare their diagnostic accuracy to those of the manufacturer-provided parameters of the RTVue-100. The ability of each parameter to diagnose glaucoma was examined by comparing the area under the receiver-operating characteristics curve (AUROC).
Results: AUROC values for the healthy vs. preperimetric glaucoma comparison were 0.842, 0.859, and 0.925 for average cpRNFLT, average R/O ratio, and average G/O ratio, respectively. For the healthy vs. early perimetric glaucoma comparison the AUROC values were 0.927, 0.933, and 0.979 for cpRNFLT, R/O ratio, and G/O ratio, respectively. Diagnostic accuracy of the R/O ratio and cpRNFLT did not differ significantly (P > 0.05). Diagnostic accuracy for the G/O ratio was significantly greater than the cpRNFLT in early glaucoma (P < 0.05).
Conclusions: Use of the G/O ratio is recommended for the detection of early glaucoma in Japanese eyes.
References
Leung CK, Chan WM, Yung WH, Ng AC, Woo J, Tsang MK, et al. Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study. Ophthalmology 2005;112:391-400.
Medeiros FA, Zangwill LM, Bowd C, Vessani RM, Susanna Jr R, Weinreb RN. Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography. Am J Ophthalmol 2005;139:44-55.
Leite MT, Rao HL, Zangwill LM, Weinreb RN, Medeiros FA. Comparison of the diagnostic accuracies of the Spectralis, Cirrus, and RTVue optical coherence tomography devices in glaucoma. Ophthalmology 2011;118:1334-1339.
Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS. Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol2005;139:39-43.
Kim NR, Lee ES, Seong GJ, Choi EH, Hong S, Kim CY. Spectral-domain optical coherence tomography for detection of localized retinal nerve fiber layer defects in patients with open-angle glaucoma. Arch Ophthalmol 2010;128:1121-1128.
Takagi ST, Kita Y, Yagi F, Tomita G. Macular retinal ganglion cell complex damage in the apparently normal visual field of glaucomatous eyes with hemifield defects. J Glaucoma 2012;21:318-325.
Tan O, Chopra V, Lu AT, Schuman JS, Ishikawa H, Wollstein G, et al. Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography. Ophthalmology 2009;116:2305-2314.
Öner V, Aykut V, Taş M, Alakus MF, Iscan Y. Effect of refractive status on peripapillary retinal nerve fibre layer thickness: a study by RTVue spectral domain optical coherence tomography. Br J Ophthalmol 2013;97:75-79.
Zhao Z, Jiang C. Effect of myopia on ganglion cell complex and peripapillary retinal nerve fiber layer measurements. a Fourier domain optical coherence tomography study of young Chinese persons. Clin Experiment Ophthalmol 2013;41:561-566.
Girkin CA, McGwin Jr G, Sinai MJ, Sekhar GC, Fingeret M, Wollstein G, et al. Variation in optic nerve and macular structure with age and race with spectral-domain optical coherence tomography. Ophthalmology 2011;118:2403-2408.
Savini G, Barboni P, Parisi V, Carbonelli M. The influence of axial length on retinal nerve fiber layer thickness and optic-disc size measurements by spectral-domain OCT. Br J Ophthalmol 2012;96:57-61.
Cheung CY, Leung CK, Lin D, Pang CP, Lam DS. Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography. Ophthalmology 2008;115:1347-1351.
Alasil T, Wang K, Keane PA, Lee H, Baniasadi N, de Boer JF et al. Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography. J Glaucoma 2013;22:532-541.
Kita Y, Naghizadeh F, Kita R, Tomita G, Holló G. Comparison of macular ganglion cell complex thickness to total retinal thickness ratio between Hungarian and Japanese eyes. Jpn J Ophthalmol 2013;57:540-545.
Holló G, Naghizadeh F, Vargha P. Accuracy of macular ganglion-cell complex thickness to total retina thickness ratio to detect glaucoma in white Europeans. J Glaucoma. 2014 Oct-Nov;23(8):e132-7.
Kita Y, Kita R, Takeyama A, Nishimura C, Tomita G. Ability of optical coherence tomography-determined ganglion cell complex thickness to total retinal thickness ratio to diagnose glaucoma. J Glaucoma 2013;22:757-762.
Kita Y, Kita R, Takeyama A, Anraku A, Tomita G, Goldberg I. Relationship between macular ganglion cell complex thickness and macular outer retinal thickness: a spectral-domain optical coherence tomography study. Clin Experiment Ophthalmol 2013;41:674-682.
Takeyama A, Kita Y, Kita R, Tomita G. Influence of axial length on ganglion cell complex (GCC) thickness and on GCC thickness to retinal thickness ratios in young adults. Jpn J Ophthalmol 2014 Jan;58(1):86-93.
Tan O, Li G, Lu AT, Varma R, Huang D, Advanced Imaging for Glaucoma Study Group. Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis. Ophthalmology 2008;115:949-956.
Vajaranant TS, Anderson RJ, Zelkha R, Zhang C, Wilensky JT, Edward DP, et al. The relationship between macular cell layer thickness and visual function in different stages of glaucoma. Eye 2011;25:612-618.
Seong M, Sung KR, Choi EH, Kang SY, Cho JW, Um TW, et al. Macular and peripapillary retinal nerve fiber layer measurements by spectral domain optical coherence tomography in normal-tension glaucoma. Invest Ophthalmol Vis Sci 2010;51:1446-1452.
Hirashima T, Hangai M, Nukada M, Nakano N, Morooka S, Akagi T, et al. Frequency-doubling technology and retinal measurements with spectral-domain optical coherence tomography in preperimetric glaucoma. Graefes Arch Clin Exp Ophthalmol 2013;251:129-137.
Mori S, Hangai M, Sakamoto A, Yoshimura N. Spectral-domain optical coherence tomography measurement of macular volume for diagnosing glaucoma. J Glaucoma2010;19:528-534.
Na JH, Lee K, Lee JR, Baek S, Yoo SJ, Kook MS. Detection of macular ganglion cell loss in preperimetric glaucoma patients with localized retinal nerve fibre defects by spectral-domain optical coherence tomography. Clin Experiment Ophthalmol 2013;41:870-880.
Kita Y, Kita R, Takeyama A, Tomita G, Goldberg I. The effect of high myopia on glaucoma diagnostic parameters as measured by optical coherence tomography. Clin Experiment Ophthalmol 2014;42:722-728.