Computer-aided identification of novel ophthalmic artery waveform parameters in healthy subjects and glaucoma patients
Vol. 1 No. 2 (2016), Original Articles
Vol. 1 No. 2 (2016)

Computer-aided identification of novel ophthalmic artery waveform parameters in healthy subjects and glaucoma patients

Original Articles
https://doi.org/10.35119/maio.v1i2.31
Published 2016-12-15
Lucia Carichino
Indiana U Purdue U Indianapolis
Giovanna Guidoboni
Department of Mathematical Sciences, Indiana University Purdue University Indianapolis, Indianapolis, IN, USA; Institut de Recherche Mathématique Avancée UMR 7501, Université de Strasbourg, Strasbourg, France; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA;
Alice Chandra Verticchio Vercellin
University Eye Clinic, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy;
Giovanni Milano
University Eye Clinic, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy;
Carlo Alberto Cutolo
University Eye Clinic, DiNOGMI, University of Genoa, Genoa, Italy;
Carmine Tinelli
Clinical Epidemiology and Biometric Unit, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy;
Annalisa De Silvestri
Clinical Epidemiology and Biometric Unit, Foundation IRCCS, Policlinico San Matteo, Pavia, Italy;
Sergey Lapin
Washington State University, Pullman, WA, USA; Kazan Federal University, Kazan, Russian Federation;
Joshua C. Gross
Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA;
Brent A. Siesky
Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA;
Alon Harris
Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Indianapolis, IN, USA
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1.
Carichino L, Guidoboni G, Verticchio Vercellin AC, Milano G, Cutolo CA, Tinelli C, De Silvestri A, Lapin S, Gross JC, Siesky BA, Harris A. Computer-aided identification of novel ophthalmic artery waveform parameters in healthy subjects and glaucoma patients. MAIO [Internet]. 2016 Dec. 15 [cited 2024 Nov. 21];1(2):59-6. Available from: https://www.maio-journal.com/index.php/MAIO/article/view/31
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Keywords

color Doppler imaging; glaucoma; image processing; ophthalmic artery; velocity; waveform parameters

Abstract

Purpose: Arterial waveform parameters (WPs) are commonly used to monitor and diagnose systemic diseases. Color Doppler Imaging (CDI) is a consolidated technique to measure blood velocity profile in some of the major ocular vessels. This study proposes a computer-aided manipulation process of ophthalmic artery (OA) CDI images to classify and quantify WPs that might be significant in the assessment of glaucoma.

Methods: Fifty CDI images acquired by four different operators on nine healthy individuals and 38 CDI images of 38 open-angle glaucoma (OAG) patients were considered. An ad-hoc semi-automated image processing code was implemented to detect the digitalized OA velocity waveform and to extract the WPs. Concordance correlation coefficient (CCC), two-sample t-test and Pearson’s correlation coefficient were used to test for similarities, differences and associations among variables.

Results: The OA-CDI images manipulation proposed showed a higher concordance between measured peak systolic velocity (PSV) data and extracted PSV data (0.80≤CCC≤0.98) than on end diastolic velocity (EDV) (0.45≤CCC≤0.63) and resistive index (RI) (0.30≤CCC≤0.58) data. In OAG patients, EDV, RI, subendocardial viability ratio (SEVR), period (T), area ratio (f) and normalized distance between ascending and descending limb (DAD/T) were found statistically correlated to at least one of the following factors: gender, age, ocular medications and year of diagnosis. When compared to healthy individuals, OAG patients OA-CDI profiles showed statistically higher values of f (p < 0.001) and DAD/T (p = 0.002) (p-values corrected by age and gender).

Conclusion: The proposed computer-aided manipulation of OA-CDI images allowed to identify DAD/T as a novel WP that vary significantly among healthy individuals and OAG patients, and among female and male OAG patients. Future studies on longitudinal OAG data are suggested to investigate the potential of DAD/T to predict severity and progression of the disease.

https://doi.org/10.35119/maio.v1i2.31
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