Vol. 2 No. 1 (2018), Original Articles

Vol. 2 No. 1 (2018)

Racial differences in the correlations between structural parameters and ocular blood flow in healthy eyes

Original Articles

https://doi.org/10.35119/maio.v2i1.57

Published 2018-02-16

Koosha Ramezani⁺⁻
Alon Harris⁺⁻
Brent Siesky⁺⁻
Carine Olinde⁺⁻
Darrell WuDunn⁺⁻
Jennifer Eikenberry⁺⁻
Fang-I Chu⁺⁻
Leslie A. Tobe⁺⁻
Betul Kaskan⁺⁻
Lyne Racette⁺⁻

Koosha Ramezani

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA; Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

Alon Harris

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Brent Siesky

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Carine Olinde

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Darrell WuDunn

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Jennifer Eikenberry

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Fang-I Chu

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Leslie A. Tobe

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Betul Kaskan

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA

Lyne Racette

Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, Department of Ophthalmology, Indianapolis, IN, USA; Department of Ophthalmology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

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Ramezani K, Harris A, Siesky B, Olinde C, WuDunn D, Eikenberry J, Chu F-I, Tobe LA, Kaskan B, Racette L. Racial differences in the correlations between structural parameters and ocular blood flow in healthy eyes. MAIO [Internet]. 2018 Feb. 16 [cited 2024 Dec. 3];2(1):29-41. Available from: https://www.maio-journal.com/index.php/MAIO/article/view/57

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Keywords

glaucoma; ocular blood flow; posterior segment; racial difference

Abstract

Purpose: This study aimed to assess differences in the relationship between structural parameters and ocular blood flow between persons of African (AD) and European descent (ED) with healthy eyes.

Methods: The relationship between structural and ocular blood flow parameters was assessed in 46 participants (20 AD, 26 ED) with healthy eyes. Disc area (DA), rim area (RA), and retinal nerve fiber layer (RNFL) thickness were measured. Retrobulbar blood flow was assessed in the ophthalmic (OA), central retinal (CRA), nasal (NPCA) and temporal short posterior ciliary arteries (TPCA). Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) were assessed. Retinal capillary blood flow was also evaluated. Differences between the correlations were determined using the Fisher r-to-z transformation.

Results: Significant differences in correlations were observed between the AD and ED groups in the CRA, where PSV and DA were positively correlated in AD (r=0.43) and negatively correlated in ED (r=-0.36) (Δr=0.79; P=0.01). A similar finding was observed for PSV and RA (AD: r=0.39; ED: r=-0.23; Δr=0.62; P=0.04). In the inferior hemifield for ED group only, percentage of avascular space and RNFL thickness were positively correlated (r=0.51, P=0.01) and mean retinal flow and RNFL thickness were negatively correlated (r=-0.50, P=0.01).

Conclusion: The relationship between structural parameters and the blood supply to the superficial layer of the retina was significantly different in the healthy eyes of AD compared to ED. More research is required to show how these differences may affect glaucomatous risk.

https://doi.org/10.35119/maio.v2i1.57

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