Ultrastructural and nanomechanical changes of the cornea following enzymatic degradation
Vol. 2 No. 2 (2018), ESB ITA
Vol. 2 No. 2 (2018)

Ultrastructural and nanomechanical changes of the cornea following enzymatic degradation

ESB ITA
https://doi.org/10.35119/maio.v2i2.67
Published 2018-06-18
Ahmed Kazaili
Department of Mechanical, Material and Aerospace Engineering, School of Engineering, University of Liverpool
Riaz Akhtar
Department of Mechanical, Material and Aerospace Engineering, School of Engineering, University of Liverpool
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Kazaili A, Akhtar R. Ultrastructural and nanomechanical changes of the cornea following enzymatic degradation. MAIO [Internet]. 2018 Jun. 18 [cited 2024 Dec. 26];2(2):24-9. Available from: https://www.maio-journal.com/index.php/MAIO/article/view/67
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Keywords

amylase; corneal biomechanics; keratoconus

Abstract

Understanding of the ultrastructure and nanomechanical behavior of the cornea is important for a number of ocular disorders. In this study, atomic force microscopy (AFM) was used to determine nanoscale changes in the porcine cornea following enzymatic degradation. Diff erent concentrations of amylase were used to degrade the cornea. A reduction in elastic modulus at the nanoscale, along with disrupted collagen morphology, was observed following enzymatic treatment. This study highlights the interplay between mechanical properties and collagen organization in the healthy cornea.

https://doi.org/10.35119/maio.v2i2.67
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