Keywords
Abstract
The study of corneal biomechanics has gained interest due to its applications on predicting refractive surgery outcomes and the study of a number of pathologies affecting the cornea. In this regard, non-contact tonometry (NCT) has become a popular diagnostic tool in ophthalmology and as an alternative method to characterize corneal biomechanics. Since identification of material parameters using NCT tests rely on the inverse finite element method, accurate and reliable simulations are required. In this work, we present a full fluid structure simulation of a NCT test accounting for the eff ect of the presence of the humors. The results indicate that when inertial effects are considered, not including humors may lead to overestimating corneal displacement, and therefore, to an overestimation of the actual corneal stiffness when using the inverse finite element method.
References
Lanza M, Iaccarino S, Bifani M. In vivo human corneal deformation analysis with a Scheimpflug camera, a critical review. J Biophotonics. 2016;9(5):464-477.
Ariza MA, Zurita JF, Piñero DP, Rodriguez Matas JF, B. Calvo B. Coupled biomechanical response of the cornea assesed by non-contact tonometry. A simulation study. PLoS One. 2016;10(3):e0121486.
Roy AS, Kurian M, Matalia H, Shetty R. Air-puff associated quantification of non-linear biomechanical properties of the human cornea in vivo. J Mech Behav Biomed Mater. 2015;48:173-182.
Hon Y, Lam AKC. Corneal deformation measurement using Scheimpflug noncontact tonometry. Optom Vis Sci. 2013;90(1):e1-e8.
Ariza-Gracia MA, Redondo S, Piñero D, Calvo B, Rodriguez Matas JF. A predictive tool for determining patient-specific mechanical properties of human corneal tissue. Comput Methods Appl Mech Eng.2017;317:226-247.
Lago MA, Rupérez MJ, Martínez-Martínez F, et al. A new methodology for the in vivo estimation of the elastic constants that characterize the patient-specific biomechanical behaviour of the human cornea. J Biomech 2015;48(1):38-43.
Elsheikh A, Joda A, Abass A, Garway-Heath D. Assesment of the ocular response analyser as an instrument for measurement of intraocular pressure and corneal biomechanics. Curr Eye Res.
;40(11):1111-1119.