Saccadic movement effects on intraocular drug delivery for a wet-AMD clinical case
Vol. 2 No. 2 (2018), ESB ITA
Vol. 2 No. 2 (2018)

Saccadic movement effects on intraocular drug delivery for a wet-AMD clinical case

ESB ITA
https://doi.org/10.35119/maio.v2i2.79
Published 2018-06-18
Marco Ferroni
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano
Matteo Cereda
Department of Biomedical and Clinical Science Luigi Sacco, Sacco Hospital, University of Milan,
Federica Boschetti
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano
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Ferroni M, Cereda M, Boschetti F. Saccadic movement effects on intraocular drug delivery for a wet-AMD clinical case. MAIO [Internet]. 2018 Jun. 18 [cited 2024 Nov. 23];2(2):86-91. Available from: https://www.maio-journal.com/index.php/MAIO/article/view/79
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Keywords

age-related macular degeneration (AMD); computational fluid-dynamics; saccade; vitreous drug delivery

Abstract

Nowadays, intravitreal injections are the gold standard for the treatment of age-related macular degeneration (AMD). The prediction of the transport mechanism for the injected anti vascular endothelial growth factor (anti-VEGF) is needed in order to understand its distribution and consumption after each injection. Thus, this study aims at implementing a full model of vitreous drug delivery. The main novelty of this work is the coupling between an experimental evaluation of the scleral permeability and a numerical analysis of the saccadic dependency of the transport phenomena.

https://doi.org/10.35119/maio.v2i2.79
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References

Stay MS, Xu J, Randolph TW, Barocas VH. Computer simulation of convective and diffusive transport of controlled-release drugs in the vitreous humor. Pharm Res. 2003;20(1):96-102. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12608542

Modareszadeh A, Abouali O, Ahmadi GG. Saccade movements effect on the intravitreal drug delivery in vitreous substitutes: a numerical study. Biomech Model Mechanobiol. 2013;12(2):281-290.doi:10.1007/s10237-012-0398-3

Xu J, Heys JJ, Barocas VH, Randolph TW. Permeability and diffusion in vitreous humor: implications for drug delivery. Pharm Res. 2000;17(6):664–669.

Romano MR, Vallejo-Garcia JL, Romano V, Angi M, Vinciguerra P, Costagliola C. Thermodynamics of vitreoretinal surgery. Curr Eye Res. 2013;38(3):371–374. doi:10.3109/02713683.2012.745160

Veurink M, Stella C, Tabatabay C, Pournaras CJ, Gurny R. Association of ranibizumab (Lucentis®) or bevacizumab (Avastin®) with dexamethasone and triamcinolone acetonide: An in vitro stability assessment. Eur J Pharm Biopharm. 2011;78(2):271–277. doi:10.1016/j.ejpb.2010.12.018

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