How to Cite
Copyright notice
Authors who publish with this journal agree to the following terms:
Authors retain copyright and grant the journal right of first publication, with the work twelve (12) months after publication simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
- After 12 months from the date of publication, authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Keywords
Abstract
One of the possible risks associated with the implant of iris-fixated phakic intraocular lenses (pIOL) is loss of corneal endothelial cells. We hypothesize that this might be due to alterations in corneal metabolism secondary to the lens implantation. To verify the feasibility of this assumption, we propose a mathematical model of the transport and diffusion of metabolic species in the anterior chamber and the cornea, coupled to a model of aqueous flow. Results are obtained both with and without the pIOL in the case of closed eyelids. The results suggest that glucose availability may be significantly reduced at the corneal endothelium. However, it must still be verified whether this finding has clinical relevance.
References
Repetto R, Pralits, JO, Siggers, JH, Soleri P. Phakic iris-fixated intraocular lens placement in the anterior chamber: effects on aqueous flow. Invest Ophthalmol Visual Sci. 2015;56(5):3061–3068.
Chhabra M, Prausnitz JM, Radke CJ. Diffusion and monod kinetics to determine in vivo human corneal oxygen-consumption rate during soft contact-lens wear. J Biomed Mater Res B Appl Biomater. 2009;90(1):202–209.
Pinsky PM. Three-Dimensional modeling of metabolic species transport in the cornea with a hydrogel intrastromal inlay. Invest Ophthalmol Visual Sci. 2014;55(5):3093–3106.
Alvord LA, Hall WJ, Keyes LD, Morgan CF, Winterton LC. Corneal oxygen distribution with contact lens wear. Cornea. 2007;26(6):654–664.
Bonanno JA, Polse KA. Corneal acidosis during contact lens wear: effects of hypoxia and CO2. Invest Ophthalmol Visual Sci. 1987;28(9):1514–1520.